Везде

RAS Chemistry & Material ScienceНеорганические материалы Inorganic Materials

  • ISSN (Print) 0002-337X
  • ISSN (Online) 3034-5588

Evaluation of Structural and Phase Transformations of Low-Temperature Calcium Phosphates under in vitro Model Conditions

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PII
S3034558825060062-1
DOI
10.7868/S3034558825060062
Publication type
Article
Status
Published
Authors
M.A. Shlykov
  • Affiliation: Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
P.V. Smirnova
  • Affiliation: Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
I.V. Smirnov
  • Affiliation: Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
A.Yu. Teterina
  • Affiliation: Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
I.S. Fadeeva
  • Affiliation:
    Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
    Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
V.V. Minaichev
  • Affiliation:
    Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
    Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
V.S. Komlev
  • Affiliation: Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
Volume/ Edition
Volume 61 / Issue number 11-12
Pages
731-742
Abstract
The article describes the processes occurring with calcium phosphates (dicalcium phosphate dihydrate, octacalcium phosphate and hydroxyapatite) obtained using a low-temperature approach, under physiological conditions, in media simulating extracellular body fluids: simulated body fluid (SBF) and phosphate buffered saline solution (PBS). Using X-ray diffraction analysis, IR spectroscopy, and scanning electron microscopy, the features of structural and phase transformations of materials during exposure in model systems for up to 56 days were revealed. It was shown that materials based on octacalcium phosphate and hydroxyapatite are stable under physiological conditions, while dicalcium phosphate dihydrate undergoes phase transformations during dissolution-crystallization process. A numerical description and evaluation of the kinetics of dissolution are presented, which can make it possible to predict the behavior of materials in the organism, their potential biological effect, and the phase transformations occurring during the integration process.
Keywords
фосфаты кальция низкотемпературный синтез кинетика деградации модельные растворы регенерация костной ткани
Date of publication
24.05.2025
Year of publication
2025
Number of purchasers
0
Views
19

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